Effects of treatment with Advair Diskus 250/50 or salmeterol 50 mcg on BMD at the L 1 -L 4 lumbar spine and total hip were evaluated in 186 subjects with COPD (aged 43 to 87 years) in a 3-year double-blind trial. Of those enrolled, 108 subjects (72 males and 36 females) were followed for the entire 3 years. BMD evaluations were conducted at baseline and at 6-month intervals. Conclusions cannot be drawn from this trial regarding BMD decline in subjects treated with Advair Diskus versus salmeterol due to the inconsistency of treatment differences across gender and between lumbar spine and total hip.
Corneal edema and cystoid macular edema are less serious but more common, and occur because of persistent swelling at the front of the eye in corneal edema or back of the eye in cystoid macular edema.  They are normally the result of excessive inflammation following surgery, and in both cases, patients may notice blurred, foggy vision. They normally improve with time and with application of anti-inflammatory drops. The risk of either occurring is around one in 100. It is unclear whether NSAIDs or corticosteroids are superior at reducing postoperative inflammation. 
Because of the high risk of varicella infection in the immunocompromised patient, postexposure prophylaxis with varicella-zoster immune globulin is recommended in the nonimmune patient. Patient with varicella-zoster infection should be treated with acyclovir and carefully monitored. [ 28 ] Varicella immunization is safe and effective in patients with INS who are in remission and off steroid treatment (with the usual precautions for administering live viral vaccines to patients who have received steroids). [ 80 ]