Nadia: Sorry for your troubles. You have just described the course of a steroid responder. Your pressure was fine for the first few weeks, but after being on a corticosteroid for several weeks your pressure began to rise. If inflammation is well controlled, most surgeons stop the steroid or switch to a weaker steroid if the pressure is hard to control. If you are on a non-steroidal anti inflammatory (NSAID), it makes it easer to get off of the steroid since these drops will still help control inflammation when the steroid is stopped. Sometimes it takes several months for the steroid pressure elevation to resolve. During that time, maximum medical management is attempted. If a patient already has weakened nerves from glaucoma, sometimes a glaucoma surgery must be used to lower the pressure and protect vision.
Corticosteroids will inhibit phospholipase A2 thereby preventing the generation of substances which mediate inflammation, for example, prostaglandins. Corticosteroids also produce a marked, though transient, lymphocytopenia. This depletion is due to redistribution of the cells, the T lymphocytes being affected to a greater degree than the B lymphocytes. Lymphokine production is reduced, as is the sensitivity of macrophages to activation by lymphokines. Corticosteroids also retard epithelial regeneration, diminish post-inflammatory neo-vascularisation and reduce towards normal levels the excessive permeability of inflamed capillaries.
Hi: This is heart breaking indeed. So, the bad news is that cataracts have begun to form, especially in one eye. The good news is that your horse still has sight out of one good eye and some sight out of the eye with the cataract. Research on Can-C reports that application of the Can-C eye drops as directed results in about 95% improvement in the subjects that were studied. Subjects have been dogs and humans – not horses – but researchers concluded that the Can-C helps reverse cataracts in all mammals including horses in, again, 95% of the cases. So, it is certainly worth a try, especially to insure that the good eye remains clear of a cataract.