Inhaled corticosteroids for asthma therapy patient compliance devices and inhalation technique

Results   Of 1326 records identified, 15 randomized clinical trials (N = 7122 patients) were included. Most trials assessed adding LAMA vs placebo or LAMA vs LABA to inhaled corticosteroids. Adding LAMA vs placebo to inhaled corticosteroids was associated with a significantly reduced risk of exacerbation requiring systemic corticosteroids (RR, [95% CI, to ]; RD, − [95% CI, − to ]). Compared with adding LABA, adding LAMA to inhaled corticosteroids was not associated with significant improvements in exacerbation risk (RR, [95% CI, to ]; RD, [95% CI, − to ]), or any other outcomes of interest. Triple therapy was not significantly associated with improved exacerbation risk vs inhaled corticosteroids and LABA (RR, [95% CI, to ]; RD, − [95% CI, − to ]).

There are no adequate and well-controlled in pregnant women; there are clinical considerations with use of inhaled corticosteroids (ICS), including beclomethasone dipropionate, in pregnant women; available human data do not establish presence or absence of drug- associated risk to fetus; in animal reproduction studies, beclomethasone dipropionate resulted in adverse developmental effects in mice and rabbits at subcutaneous doses equal to or greater than approximately times maximum recommended human daily inhalation dose (MRHDID) in adults ( mg/day); in rats exposed to beclomethasone dipropionate by inhalation, dose-related gross injury to fetal adrenal glands was observed at doses greater than 180 times the MRHDID, but there was no evidence of external or skeletal malformations or embryo lethality at inhalation doses up to 440 times the MRHDID

When you take the normal dose, side effects are usually uncommon and mild. hey usually occur if you take the larger dose by puffing twice rather than four times a day. The most common effects include coughing fits, headache, sore throat, dry mouth and hoarseness. Less common effects include a slight nosebleed, constipation and trouble sleeping. After prolonged use, high blood pressure can sometimes occur in the eyes and potentially trigger glaucoma. If this happens, stop taking your medications and contact your doctor. In children, there's also the possibility of a very slight reduction in growth by about an inch on average, but no other unique side effects exist.

Inhaled corticosteroids for asthma therapy patient compliance devices and inhalation technique

inhaled corticosteroids for asthma therapy patient compliance devices and inhalation technique

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inhaled corticosteroids for asthma therapy patient compliance devices and inhalation techniqueinhaled corticosteroids for asthma therapy patient compliance devices and inhalation techniqueinhaled corticosteroids for asthma therapy patient compliance devices and inhalation techniqueinhaled corticosteroids for asthma therapy patient compliance devices and inhalation techniqueinhaled corticosteroids for asthma therapy patient compliance devices and inhalation technique

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