Compare cell signaling mechanisms steroid hormones

Predicted anticancer drugs inhibit the growth of neuroendocrine tumor cells. Multi-tyrosine kinase inhibitors sorafenib, sunitinib, regorafenib and cabozantinib effectively inhibit GOT1 cell growth with IC50 values in the micromolar range. Inhibitors of AKT (MK-2206), HDAC (vorinostat), HSP90 (alvespimycin) and CDK4/9 (P276-00) also inhibited GOT1 cell growth at micromolar concentrations, whereas inhibition of PARP1 (veliparib) had no effect. GOT1 cells were treated with anticancer drugs at various concentrations for 4 days. Cell viability was estimated using AlamarBlue®. Data points are the mean values of three individual experiments carried out in triplicate (n=9). Fitting of curves was done in GraphPad Prism software using log (inhibitor) vs response nonlinear fit with variable slope. IC50 was interpolated at Y=50 and bars denote ±.

Compare cell signaling mechanisms steroid hormones

compare cell signaling mechanisms steroid hormones

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compare cell signaling mechanisms steroid hormonescompare cell signaling mechanisms steroid hormonescompare cell signaling mechanisms steroid hormonescompare cell signaling mechanisms steroid hormonescompare cell signaling mechanisms steroid hormones

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